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KMID : 0387920070180010069
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Korean Journal of Cytopathology
2007 Volume.18 No. 1 p.69 ~ p.73
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Invasine Ductal Carcinoma with Osteoclast-Like Giant Cell in a Young Woman
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Kang Hyun-Jeong
Choi Kyung-Un
Kwak Hee-Suk
Sol Mi-Young
Kim Jee-Yeon
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Abstract
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Mammary carcinoma with osteoclast-like giant cells is an unusual neoplasm characterized by giant cells, mononuclear stromal cells, and hemorrhage accompanying a low grade carcinoma. We present the cytological findings in a case of invasive ductal carcinoma with osteoclast-like giant cells that was initially confused with a fibroadenoma, due to its well-demarcated and soft mass and the young age of the patient. A 28-year-old female presented with a 4.5 cm, well demarcated, soft and nontender mass in the right breast. Fine needle aspiration cytology (FNAC) showed a combination of low grade malignant epithelial cell clusters and osteoclast-like giant cells. The atypical epithelial cells were present in cohesive sheets and clusters. Osteoclast-like giant cells and bland-looking mononuclear cells were scattered. An histological examination revealed the presence of an invasive ductal carcinoma with osteoclast-like giant cells. We report here the cytological findings of this rare carcinoma in a very young woman. The minimal atypia of the epithelial cells and its soft consistency may lead to a false negative diagnosis in a young woman. The recognition that osteoclastlike giant cells are rarely present in a low grade carcinoma, but not in benign lesion, can assist the physician in making a correct diagnosis.
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KEYWORD
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Osteoclast-like giant cell, Cytology, Aspiration, Breast, Young woman
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